Voltage-gated ion channels
نویسندگان
چکیده
differentiated newt cells, but not in their mammalian counterparts. There has been some progress along these lines but not at the level of pinpointing the genetic differences. It is important to remember that there are examples, such as the axolotl lens, where a particular tissue does not regenerate even though the animal is capable of regenerating other structures. Such a context may be more favourable experimentally to identify what makes a tissue regeneration competent.
منابع مشابه
Voltage-Gated Sodium Channels Modulation by Bothutous Schach Scorpion Venom
Buthotus schach is one of the dangers scorpion in Iran that belong to the Buthidae family. Toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as pharmacological tools. In the present study, we investigated the effect of venom and its obtained fractions by gel filtrations on electrophysiolog...
متن کاملAntiepileptic Drug Targets: An Update on Ion Channels
Different mechanisms of action have been proposed to explain the effects of antiepi‐ leptic drugs (AEDs) including modulation of voltage‐dependent sodium calcium and potassium channels, enhancement of γ‐aminobutyric acid (GABA)‐mediated neuronal inhibition, and reduction in glutamate‐mediated excitatory transmission. Recent advances in understanding the physiology of ion channels and genetics b...
متن کاملFluorescence imaging of electrically stimulated cells.
Designing high-throughput screens for voltage-gated ion channels has been a tremendous challenge for the pharmaceutical industry because channel activity is dependent on the transmembrane voltage gradient, a stimulus unlike ligand binding to G-protein-coupled receptors or ligand-gated ion channels. To achieve an acceptable throughput, assays to screen for voltage-gated ion channel modulators th...
متن کاملDeep Insight Section
Ion channels are pore-forming proteins and their function is to facilitate the diffusion of ion across cell membranes by flow of ions down the electrochemical gradient. Voltage-gated ion channels are a class of transmembrane ion channels and are found throughout the body which allowed a rapid and coordinated depolarization in response to voltage change in excitable cells (Catterall, 2010). Rece...
متن کاملInternational Union of Pharmacology. XXXIX. Compendium of voltage-gated ion channels: sodium channels.
This summary article presents an overview of the molecular relationships among the voltage-gated sodium channels and a standard nomenclature for them, which is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels. The complete Compendium, including data tables for each member of the sodium channel family can be found at .
متن کاملEvolutionary Analysis of Biological Excitability
Excitability is an attribute of life, and is a driving force in the descent of complexity. Cellular electrical activity as realized by membrane proteins that act as either channels or transporters is the basis of excitability. Electrical signaling is mediated by a wave of action potentials, which consist of synchronous redistribution of ionic gradients down ion channels. Ion channels select for...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current Biology
دوره 15 شماره
صفحات -
تاریخ انتشار 2005